A fellow homebrew friend offered many different samples of the same Pale Ale recipe with different generation yeast at a club meeting. The yeast used was US-05 from 1st pitch up to 10th generation repitch. I could not tell a difference among them. We did not do a triangle test and there were 5 different samples, but I couldn't tell a difference at all. Maybe a different yeast strain with less of a neutral profile would be more suitable for an experiment.