I worried about this too with my system, as it holds 2 gallons under the false bottom. However, I don't feel that the quality of the beer is any different than when I used a bazookah screen and less total water.
The main concern, to me, about higher liquid to grain ratios manifests in the pH. The grain supplies the organic acids and the water supplies the calcium and alkalinity. If you have a lower total volume of water, then the available alkalinity is less and easily consumed. If you have to use more water, then there is more residual alkalinity to impact pH. Unless you have very alkaline water, this is a minor problem, maybe only 0.1 pH units. However, if you have moderate to high alkalinity, then the pH could be off (basic) by 0.2-0.4, which could put you in the 5.8 pH range and enzyme activity could be reduced. You can either add a little acid to correct or simply give the enzymes a little more time to work. If making dark beers with dark kilned, acidic grains, then you probably won't ever notice.