I use both tri-clamps and cam-locks depending upon the application. One thing I'd like to do, however, is migrate to all of one or the other. In my situation, it's not possible to go one way or the other, but whatever you decide be consistent.
Just my 2 cents, but there's a reason why most (if not all) commercial brewing equipment is fitted with tri-clamps. But then again, for homebrewing purposes cam-locks would be fine.