Go to McSorley's just to have a pint among the frat-types, and then go a few doors east to Burp Castle.
Here's a tap list example: Boon Kriek, SouthernTier Creme Brûlée, Piraat, Saison Dupont, Allagash Curieux, Old Golden Hen, Corsendonk Tripel, Blackthorn, Duchesse de Bourgogne, Wells Banana Bread, Mikkeller Centenial IPA, Radeberger Pilsner. I wonder how much they want for a pint of Duchesse. I can get it for 2 eur here...
After Burp Castle, go to Standings for a good selection of craft pints, but an even better atmosphere for watching a game. Then go further east to the corner and slightly north to Pommes Frites, or a bit further north to Paul's burger joint. Then go back south, east again to Velvet lounge and smoke yerself some cigars.
That was my friday night ritual for a few years, not always the same order of course. Never fails. Also you can go a bit south to the Houston Whole Foods, they have a pretty great beer shop and at least 4 growler taps.
Also great is Blind Tiger, and from there you can walk a "few" blocks over to Spotted Pig, which has an excellent (Sixpoint-made I think?) bitter on hand pump.