I am definitely leaning towards Columbus and Mt. Hood with a third in the mix, possibly one of the citrusy ones, Centennial or Citra perhaps.
I agree the Simcoe/amarillo combo is awesome. I brewed a pale ale with Simcoe/Amarillo/Cascade, but I wanted something a bit different this time around.
I am now wondering about the yeast... I always use 1056, and there's nothing wrong with it, but what about Wyeast 1272, 1332 or 1450? Any opinions on these to help someone who's never used them?