I like stainless steel camlock fittings in my brewery. Very quick, but they don't seal off when you remove the hose. So you have to be quick or there will be wort or water all over the place. Self sealing quick connects would be great except that they tend to collect debris like hops and grain in them.
I've just learned how to live with the camlocks.
After a little hot liquid spilled inside of my gloves once, I came up with a system to prevent spills when changing hoses. So, to the extent this might help others (or maybe it was an obvious solution), here's what I do:
All of your valves are closed. Open the purge valve/sampling port on the pump output. Open one of the cam arms on the high side of the fitting. The liquid level in the hose will drop. When it drops into the comfort zone for moving the hose around, close the purge valve. Carefully move the hose.
This does require that you repurge the air on the intake side of the pump. But if I can avoid another burn, I can deal with repurging.