Wait for fermentation to complete before adding the bourbon (should be done at 2 weeks anyway) then it won't matter. Take a gravity reading before adding bourbon. It will change final gravity, but you probably care more about abv. 16oz of 80 proof bourbon added to 5G of beer will raise the abv by 0.97%.
The calculation is.
abv of bourbon * volume of bourbon
------------------------------------
(volume of beer + bourbon)
so
(40%abv * 16oz) / (640oz + 16oz) = 0.97%abv