Any information on Portland is also welcome here. We have been a few times, but have only scratched the surface. Going again in late April. The brewery scene is dynamic, so I'm sure we will have more to explore.
A few others from our experience.
Powell's City of books.
The farmers market.
Widmer Gasthouse for the Altbier and German food. Yeah Widmer, if you like German.
Higgins Restaurant and Bar is a favorite, go to the bar side, unless you want a full fancy dinner.
Near Pioneer Square are a couple of parking lots ringed by food stands/carts. Wonder smells walking by.
Horse brass pub is a classic. We were there when Don Younger was still alive.
The Nob Hill area was full of bars and restaurants, and had a Laurelwood Brewing pub, and New Old Lompoc.
Drive the gorge, see the waterfalls, there is a great viewpoint on the west end of the gorge.
Mt. Hood, go up to the hotel.
Hood River OR is a fun little town. Logsdon Farmhouse ales is near there, I think there is now a rating room, look up the hours.
Do some research on the public transportation system. It is fairly good, and the downtown has the free zone, where you just hop on and off. Pretty nice for a drinking tour.