Yes, it depends.
Have you ever read the "Hop Atlas" from Barth-Haas? The wife got it for me through the interloan program through Michigan State, had to read it in 2 weeks and return. At $200+ it was a little spendy for me. It was pointed out that there were large hop growing areas south of San Francisco, around Sacramento, and in Sonoma County (the town of Hopland got it name form hop growing). Those went away when the land was more valuable for housing, or grape production.
This is in Sonoma County. Some pictures of the Kilns, the tasting is in a former kiln.
I know about hop growing in the Russian River Valley, which is in Sonoma County. That's where OY1 was selected by E.C. Horst. OY1 is the male parent of OB21 (Brewers Gold x California Cluster), which is the male parent of Northern Brewer (Canterbury Golding x OB21), which makes Northern Brewer 1/4th California Cluster.
At 38.9731° N, 123.1164°, Hopland, California is basically at the 39th parallel.
So from your post, get the right variety for you latitude and climate. Correct?
Climate pretty much determines if a hop cultivar will grow. Photoperiod determines the extent to which many of the prized cultivars will flower. North Carolina lies at the 35th parallel, which the furthest south that hops can be grown profitably. North Carolina has its own hop research program. www.indyweek.com/indyweek/is-there-a-future-for-north-carolina-hops-farming/Content?oid=3100964
In the article linked above, the author mentions importance of the 16-hour photoperiod. The closer one gets to 16 hours of daylight during the summer solstice, the better most hop cultivars produce. It's a big part of the reason why Yakima can establish hop cultivars quickly.
Yakima 2014 Summer Solstice
Day length: 15 hours and 50 minutes
I know guys who grew hops fairly successfully in SC. I have talked to ones who said their hops died in Florida. The latitude can't be ignored, for sure - none are grown in the tropics.
I am willing to bet that the guys in South Carolina are growing less photoperiod sensitive cultivars such as Cascade and Chinook. I am also willing to bet that they do not get pounds of cones out of each plant.