I have a hardware store within walking distance from my house that sells some brewing/winemaking supplies. They're good for last minute things (dry yeast in particular), or for equipment (buckets/better bottles/cleaning supplies, etc.). But they don't sell bulk grains, and they have a rather small hop supply (stored warm), so I can't really use them as a LHBS.
My nearest bona-fide homebrew shop is about 20-30 minutes away. They're only open odd hours, so it's tough to get there for me. They also only carry White Labs, but I use a lot of Wyeast. They're friendly enough, but they've been around for like 20 years and their information is just as old. Needless to say, I don't use them a whole lot. MoreBeer is more like a local homebrew shop to me than they are.