I haven't done a lot of long distance travel lately, but New England is chock full of awesome breweries that keep me pretty busy. A friend introduced me to planning hiking and kayaking day trips around the local brew pubs
Some of the local favorites:
Portsmouth Brewery (Portsmouth, NH)
Flying Goose (New London, NH)
Cape Ann Brewery (Gloucester, MA)
Northampton Brewery (Northampton, MA)
7 Barrel (somewhere in VT)
and some I have yet to visit, but love their beer:
The Tap (Haverhill Brewery, Haverhill, MA)
Tuckerman (NH)
Smuttynose Brewery (Portsmouth, NH)
Harpoon Brewery (Windsor, VT)
Ipswich Brewery/Mercury Brewing (Ipswich, MA - brewpub opening soon)
Ahhh... so many brewpubs, so little time!