Jim,
I grew up in that area and can tell you it's somewhat of a craft beer deadzone. They're are a few newer breweries, but nothing exciting IMO. Tampa is 2 hours north (tons of great spots between that and St. Pete) and Ft. Laud/Miami is 1.5 hours from Naples across Alligator Alley.
J. Wakefield in Miami is one of the best right now IMO, lots of great sours, "florida weisse" beers to be had.
There is a Total Wine in Ft. Myers which is close to Naples.