Dave Logsdon has said that its (paraphrasing) virtually impossible to over oxygenate. I tend to lean more that way than Zainasheff's presumption of why a friends beer seemed fusel. I remember the episode. Its a draw back of these info sources like podcasts. Its Jamil, so everything said is fact. Well, some of it is and some is just them discussing possibilities. I took him to be postulating on why a buddy's beer seemed to be a little hot and he thought the o2 amount the guy used seemed high. Well, could be. But maybe not. In the same discussion, Palmer mused that perhaps too much oxygen would be placing yeast cells in a pure oxygen environment till they died, but short of that the extra o2 is going to dissipate before the yeast have time to do anything about it.
Besides, does it even make sense? When do yeast uptake o2? What are they doing at that time? What are fusels? When are yeast making that? The extra o2 is long gone before alcohol is produced, seems to me anyway.
I think that there's a narrow band of not enough oxygen, then a wider band of what could be considered enough oxygen to work, maybe in that wider band there is a precise point we could call optimum, but that point probably moves around depending on wort composition and yeast strain. My money is on the bet that harmful over oxygenation is probably hard to accomplish without pressure and time.