I would advocate checking the mash pH, after about 10-15 minutes of achieving a stable temperature.
If you are single-infusion mashing, Martin's spreadsheet should give you an incredibly accurate prediction of what you can expect.
Make sure you are mashing for the grain you are using...Not necessarily the style you are brewing.
Obviously, you want to take guidelines & typical characteristics into account...
But, your particular malt will demand steps that allow you to achieve those characteristics.
For adjustment on the fly, lactic acid is probably your quickest tool.
But, you may end up being able to taste its roughness in the finished product.