About 10-12 years ago, I had a nasty pediococcus infection in my brewery, which came about the same time I was brewing lambics. Think I threw out at least 4 batches. I did get rid of it, eventually, through a combination of bleach soaks, heat, and quaternary ammonium.
Now I have a low level brett infection, which slightly sours some long sitting beers. I haven't decided whether to get rid of it yet or not. I am preferring the soured keg of doppelbock over the too sweet unsoured version that I had at Christmas.