If you built your own kegerator, or need to change out your gas lines, you should test for leaks using a soap solution. Take some liquid dish soap and make some "bubble juice" by putting a tablespoon or so in a cup of water.
Apply the bubble juice liberally at all joints along your gas lines, starting at the CO2 tank and working your way all the way to the kegs. Brush on the bubble juice and if there are CO2 leaks, you will see them because it will cause bubbles to form.
Whenever you see bubbles, tighten or replace and test again.
Then, wait a day and test it again.
Repeat this regimen daily until you no longer get any leaks twice in a row.
It really sucks if you don't know you are leaking and you go to pull a pint and your new 20lb tank is empty. Ask me how I know.