Both strains work better 2nd generation, IMO. And both produce pretty similar beer fermented at around 62º F - with US-05 being somewhat more powdery and higher-attenuating than BRY-97.
The biggest difference, IMO, is that BRY-97 is much more temperature-sensitive. I have successfully fermented with 1st-generation US-05 as low as 52º F, and I usually ferment with US-05 around 58º F - 62º F. BRY-97 WILL ferment at 58º, but I have been unable to take it cooler than that. Typically, I find BRY-97 is happy and best from 62º F - 66º F. Any colder and the fermentation is slow and lag is unacceptable. Any warmer and the esters are too much for my taste. US-05, by contrast, can ferment pretty effectively from 56º F - 68º F. As such, I consider US-05 more versatile and user-friendly, especially when fermenting at ambient during cooler months (sometimes I will brew too much for my fermentation freezer to handle around March/April).
I use both quite frequently, as well as Imperial Joystick (purportedly Pacman), which is very cold-tolerant and fairly flocculant.