I fill pretty full (basically, as full as I can get), but the risk of beer getting into the gasline is something to watch. The main thing I've found is that I've had to be careful with my pressure balance--i.e., make sure the pressure in the keg is always less than the pressure in my gas line-in, etc. I've had a few refluxes into the gas line over the years, and it's annoying to have to change out the tubing.