Things I've recently found made a significant difference for me, worthy of more disciplined analysis (no particular order):
•SO4/Cl ratio, and other minerals (Na, Mg)
•Low intensity, lid-on boil (evap. rate <8%)
•COLD side O2 avoidance (closed transfers, purging, etc.)
•Mash: no rests <153°F (single conversion rest) and a good 15-20 min @170°F
Adopting these practices (I might think of more) has been inspired largely by info shared here on the forum (the mash program is more the result of my own experience and study.)