I grew up on a farm and have a vineyard even today. I also study food, gmo's, etc. I know that when treating for unwanted pests, bugs or plants, a diversified approach is always superior, biologically speaking. For instance, if I treat for two years in a row with the same pesticide in the vineyard, I absolutely have bugs that the pesticide will not kill at the end of that time. It's the biggest issue in herbicides policy recently, where we have weeds that cannot be killed - actually first became a problem in your neck of the woods Denney. I cannot imagine that the microbes in a brewery are any different. I usually make sure to use 2 or 3 different kinds of sanitizers throughout the year.
By the way, note that hospitals are now hotbeds for staph in part because of over- reliance on one treatment. Life at the level of microbes adapts really quickly.
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