Most DME tends to be around 43 PPG, whereas light / pale all-grain tends to be around 35-38 PPG, so you need about 120% (+/-) as much grain poundage as the DME it calls for.
For example, 4.5 pounds of DME would require about 5.2 to 5.4 pounds of all-grain malt to produce the same amount of sugars, +/-.
The wheat DME that I have used (Briess, I think) is 65% wheat, 35% pale or pils. So 2 pounds of that DME would require about 24-25 oz of wheat malt and about 12-13 oz [more] of the pale malt in addition to the 5.2-5.4 pounds listed above (so, i.e., about 6 pounds total of pale, 1.5 pounds of wheat).
Mashing that high might get you a bit less fermentable sugars, so my rough estimates above might undershoot it relative to DME. I don't have much experience mashing that high, so hopefully a more experienced brewer can adjust what I've said here.