Mt. Hood and Vanguard are okay, but really aren't the real deal. I do use them for bittering, but like to stick to Saaz, Tetts, Hallertauh, Lublin for flavor/aroma.
The one NW I did not care for in a pils was Santiam. Personal taste, of course.
I have made NW hop pilsners with Cascades before, and NW 2row, and the resulting beer tasted just like Henry Weinhardts (the cream colored label) or Leinie's Northwoods lager. A nice hot summer beer.