The general atmosphere of your pub should have a lot to do with it...if there is any sort of thematic strain to it (what sort of food is served, general decorating or atmosphere, what kind of beer in general) you should go with something along those lines. If it is going to be a more conventional American brewpub (ie., some sort of spinach dip with chips on the appetizer menu, jalapeno poppers, burgers and pizza, etc., and an american pale ale, a wheat beer, and a dry stout at least always on tap), then you have to get more imaginative and the regional history associated with the building would be my first guess. Explore the history of the prior tenants, perhaps.