Extract efficiency is much greater on large systems. On a 10bbl system you might get 2-3x the extract efficiency as you would on a homebrew scale. The only way to really know would be to brew a batch and send a sample to a lab to calculate IBU.
Supply line issues are going to be a normal issue with brewing, especially with hops, with so few being grown and so much demand, especially with the proprietary strains. If I were to make recipes, I would tailor them around well-established and non-proprietary strains, like the ones released by the USDA in Corvallis.