Drink lots of water - alternate between sample glasses of water and beer. Walk the whole floor looking only for one style of beer, say milds or another lighter beer. While doing this make a note of what you want to taste on your second round, perhaps Belgians. If you are still up for it go all out on the third round, say smoked beers, double IPA, or sour beers.
That's what I do anyway. You could just as easily look for breweries you've always wanted to experience and stop in for a beer there, but sometimes you will spend a lot of time in long lines with that strategy.
Some breweries only bring enough beer for the first couple of sessions, but you can't predict which ones will be out of beer by Saurday afternoon. New Glarus has run out early in the past, so if you like sour beers, check them out on your first session.
The floor is organized by geographic regions, so you can go to a region that doesn't distribute in your area and skip the ones available any old time.
There is so much good beer that you can't really have a "bad" strategy, can you?