I'm making a small IPA, all late hop additions. Hop combination I've never tried either. Here is my original water report.
Cal: 50, Mg: 18, Na: 6, Sulfate: 5, Cl: 6, Bicarb: 220.8
And here is what I plan to do this weekend, opinions welcomed, I'm trying to learn beersmith and use Kai's spreadsheet... as well as hoping to make a decent brew.

Hopper
Brew Type: All Grain Date: 6/19/2010
Style: American IPA Brewer: Dean
Batch Size: 5.50 gal Assistant Brewer:
Boil Volume: 6.51 gal Boil Time: 60 min
Brewhouse Efficiency: 75.00 % Equipment: C70E MT 5 gallon batches
Actual Efficiency: 0.00
Taste Rating (50 possible points): 35.0
Ingredients Amount Item Type % or IBU
9 lbs 8.0 oz Pale Malt, Maris Otter (3.0 SRM) Grain 85.35 %
1 lbs Wheat Malt, Bel (2.0 SRM) Grain 8.98 %
8.0 oz Caramel/Crystal Malt - 40L (40.0 SRM) Grain 4.49 %
2.1 oz De-Bittered Black Malt (Dingemans) (550.0 SRM) Grain 1.17 %
0.0 oz Carared (20.0 SRM) Grain 0.00 %
0.50 oz Columbus (Tomahawk) [14.00 %] (20 min) Hops 13.2 IBU
1.00 oz Amarillo Gold [8.50 %] (15 min) Hops 13.1 IBU
0.50 oz Columbus (Tomahawk) [14.00 %] (10 min) Hops 7.9 IBU
0.50 oz Cascade [5.50 %] (10 min) Hops 3.1 IBU
0.50 oz Columbus (Tomahawk) [14.00 %] (5 min) Hops 4.4 IBU
0.50 oz Cascade [5.50 %] (5 min) Hops 1.7 IBU
0.50 oz Amarillo Gold [8.50 %] (5 min) Hops 2.6 IBU
1.00 oz Columbus (Tomahawk) [14.00 %] (0 min) Hops -
1.00 oz Amarillo Gold [8.50 %] (0 min) Hops -
1.00 oz Cascade [5.50 %] (0 min) Hops -
0.70 ml Lactic Acid (Mash 60.0 min) Misc
0.90 ml Lactic Acid (Boil 60.0 min) Misc
1.00 gm Epsom Salt (MgSO4) (Mash 60.0 min) Misc
3.00 gm Calcium Chloride (Mash 60.0 min) Misc
3.00 gm Gypsum (Calcium Sulfate) (Mash 60.0 min) Misc
1 Pkgs American Ale (Wyeast Labs #1056) Yeast-Ale
Beer Profile Estimated Original Gravity: 1.057 SG (1.056-1.075 SG) Measured Original Gravity: 1.000 SG
Estimated Final Gravity: 1.014 SG (1.010-1.018 SG) Measured Final Gravity: 1.000 SG
Estimated Color: 12.5 SRM (6.0-15.0 SRM) Color [Color]
Bitterness: 46.1 IBU (40.0-70.0 IBU) Alpha Acid Units: 15.5 AAU
Estimated Alcohol by Volume: 5.66 % (5.50-7.50 %) Actual Alcohol by Volume: 0.00 %
Actual Calories: -2 cal/pint
Mash Profile Name: Single Infusion, Medium Body, Batch Sparge Mash Tun Weight: 13.00 lb
Mash Grain Weight: 11.13 lb Mash PH: 5.4 PH
Grain Temperature: 72.0 F Sparge Temperature: 168.0 F
Sparge Water: 4.37 gal Adjust Temp for Equipment: TRUE
Name Description Step Temp Step Time
Mash In Add 13.91 qt of water at 169.4 F 154.0 F 60 min
Mash Notes
Simple single infusion mash for use with most modern well modified grains (about 95% of the time).
Carbonation and Storage Carbonation Type: Kegged (Forced CO2) Carbonation Volumes: 2.5 (2.2-2.7 vols)
Estimated Pressure: 12.3 PSI Kegging Temperature: 40.0 F
Pressure Used: -12 Age for: 3.0 Weeks
Storage Temperature: 52.0 F
Notes
Estimated RA: 68