I've only ever used Hop Shot, and I stick to the rule of thumb of 1 mL = 10 IBU in 5 gallons of 1.050 wort, when boiled for 60 minutes. I generally only use it in IPA's with a whole lot of late hops, so hitting a specific IBU number is less important to me. I generally add 3 mL at 60 minutes for a 3 gallon batch in the 1.055 range, and let my whirlpool hops carry the rest of the IBU's.
I'm sure the actual AA% becomes quite important in a commercial brewery trying to replicate a recipe. At the homebrew level I don't know if that level of precision is necessary (or even possible TBH). Even after an hour of boiling, I still see a fair amount of hop extract globules floating around, leading me to believe that utilization isn't necessarily consistent.