I bottle exclusively (I know, glutton for punishment) and based on experience I'm to the point where I never open one until the three week mark – it's just a waste of 22 oz of beer to do so. Often the difference in carbonation (and sometimes flavor) between 14 days and 21 days, for whatever reason, is night and day. Doesn't matter if I shake the bottles periodically or age in the high 70s, 4% beer or 8%, high or low CO2 volume.